姓名

吴建平

出生年月

1968年11月

单位

77779193永利官网

所属学科

基础医学-药理学与毒理学-神经药理

职称、职务

教授

E-mail

biojpwu@gmail.com

联系方式（办公电话）

18062552085

研究方向

1.离子通道病理

2.脑血管病、癫痫新药创新

个人简介

吴建平，男，1968年11月生，博士，教授，博士研究生导师，77779193永利官网教授；从事神经药理方向的研究工作。

2018~2023任首都医科大学附属北京天坛医院、首都医科大学人脑保护高精尖创新中心、国家神经系统疾病临床医学研究中心学科带头人；1999至2018年， 分别受雇Virginia Tech、Washington University in St Louis, University of Alabama at Birmingham，担任助理教授、研究员、研究员助理等职位。2014～2017年曾兼任湖北医药大学太和医院神经内科教授，并入选2015年度湖北省第五批“百人计划”创新人才特聘专家。长期从事离子通道、受体及转运蛋白结构与功能的基础研究，在内向整流钾通道（Kir & KATP）、钠激活钾通道K(Na)、多巴胺受体（DA）、碳酸氢钠共转运子（NBC)构效关系及其在相关病理生理条件下的作用机制有深入的研究。近年来研究兴趣侧重于离子通道、受体在脑血管病、癫痫等重要神经系统疾病的发病机制中作用及临床干预对策研究。

代表作

主持国家自然科学基金、NIH， DOD研究基金10余项，发表包括PNAS、eLife、J Neurosci、Current Neuropharmacol论文70余篇。

1) Jiang PZ, Zahra A, Guo X, Wu J*. Potential role of Sinomeninein cancer management. Pharmacology 2024(in press)

2) Liu R^#, Sun L^#, Du L^#, Guo X, Jia M, Wang Q, Wu J*. Enhanced K_Na1.1 Channel Underlies Cortical Hyperexcitability and Seizure Susceptibility after Traumatic Brain Injury.

eLife 2023 Dec 26, 12:RP93304. doi.org/10.7554/eLife.93304.1

3) Jia M^#, Guo X^#, Liu R, Sun L, Wang Q, Wu J*. Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury. Cell Mol Neurobiol. 2023 Dec 17;44(1):5. doi: 10.1007/s10571-023-01435-4.

4) Liu R, Sun L, Shi X, Li C, Guo X, Wang Y, Wang X, Zhang K, Wang Y, Wang Q, Wu J*. Increased Expression of K_Na1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury. Neurochem Res. 2023 Oct 25. doi: 10.1007/s11064-023-04044-1.

5) Guo X, Liu R, Jia M, Wang Q, Wu J*. Ischemia Reperfusion Injury Induced Blood Brain Barrier Dysfunction and the Involved Molecular Mechanism. Neurochem Res. 2023 Aug;48(8):2320-2334. doi: 10.1007/s11064-023-03923-x.

6) Zahra A, Liu R, Wang J, Wu J*. Identifying the mechanism of action of the Kv7 channel opener, retigabine in the treatment of epilepsy. Neurol Sci. 2023 Jul 13. doi: 10.1007/s10072-023-06955-x.

7) Liu R, Sun L, Wang YF, Wang Q, Wu J*. New use for an old drug: quinidine in KCNT1-related epilepsy therapy. Neurol Sci. 2023 Apr; 44(4):1201-1206. doi: 10.1007/s10072-022-06521-x.

8) Zahra A, Liu R, Han W, Meng H, Wan Q, Wang Y, Campbel SL, Wu J*. K_Ca-Related Neurological Disorders: Phenotypic Spectrum and Therapeutic Indications. Curr Neuropharmacol.2023;21(7):1504-1518. doi: 10.2174/1570159X21666221208091805.

9) Xiong H, Wu J*, Qin HL*. [3+2]Cycloaddition for the assembly of indolizine-based heterocyclic sulfonyl fluorides. Org Chem Front 2022 Nov 22. doi: 10.1039/D2QO01466A

10) Wang J^#, Zahra A^#, Wang Y, Wu J*. Understanding the physiological role of electroneutral Na+-coupled HCO3− cotransporter and its therapeutic implications. Pharmaceuticals (Basel). 2022,15, 1082. doi.org/10.3390/ph15091082.

11) Zhang Q, Jia M, Zahra A, Wang Y, Wang Q, Campbell SL, Wu J*. Cell death in cerebral ischemia-reperfusion injury. Neurochem Res. 2022 Aug 17. doi: 10.1007/s11064-022-03697-8. Epub ahead of print. PMID: 35976487.

12) Xia H, Zahra A, Jia M, Wang Q, Wang Y, Campbell SL, Wu J*.Na⁺/H⁺exchanger 1, a potential therapeutic drug target for cardiac hypertrophy and heart failure. Pharmaceuticals (Basel). 2022 Jul 15;15(7). doi: 10.3390/ph15070875.

13) Jia M, Zhang Q, Guo X, Liu R, Liu S, Chen N, Wang YF, Wang Q, Wu J*, Campbell SL. Na⁺/HCO₃^-Co-transporters Inhibitor S0859 Attenuates Global Cerebral Ischemia-reperfusion Injury of the CA1 Neurons in the Gerbil's Hippocampus.CNS Neurol Disord Drug Targets. 2022 May 17; doi: 10.2174/1871527321666220517121135.

14) Zahra A, Wang Y, Wang Q, Wu J*. Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability.Behav Neurol. 2022; 2022:5893519. doi: 10.1155/2022/5893519.

15) Zahra A, Du L, Jia M, Butt MU, Wang Q, Wang Y, Wu J*. Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice.J Integr Neurosci.2022 Mar 23;21(2):61. doi: 10.31083/j.jin2102061.

16) Sun L, Liu R, Yang H, Yu T, Wu J*, Wang Q*. Characteristics of Epileptiform Spike-wave Discharges and Chronic Histopathology in Controlled Cortical Impact Model of Sprague-Dawley Rats.Neurochem Res. 2022 Feb 1;. doi: 10.1007/s11064-022-03542-y.

17) Liu R, Sun L, Wang Y, Jia M, Wang Q, Cai X*, Wu J*. Double-edged Role of K_NaChannels in Brain Tuning: Identifying Epileptogenic Network Micro-Macro Disconnection.Curr Neuropharmacol. 2022;20(5):916-928. doi: 10.2174/1570159X19666211215104829.

18) Du L, Zahra A, Jia M, Wang Q, Wu J*. Understanding the Functional Expression of Na⁺-Coupled SLC4 Transporters in the Renal and Nervous Systems: A Review.Brain Sci. 2021 Sep 26;11(10). doi: 10.3390/brainsci11101276.

19) Sun L, Shan W, Yang H, Liu R, Wu J*, Wang Q*. The Role of Neuroinflammation in Post-traumatic Epilepsy.Front Neurol. 2021;12:646152. doi: 10.3389/fneur.2021.646152.

20) Lu M, Jia M, Wang Q, Guo Y, Li C, Ren B, Qian F, Wu J*. The electrogenic sodium bicarbonate cotransporter and its roles in the myocardial ischemia-reperfusion induced cardiac diseases.Life Sci. 2021 Apr 1;270:119153. doi: 10.1016/j.lfs.2021.119153.

21) Martinez-Espinosa PL^#, Wu J^#, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ. Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.elife. 2015 Nov 11;4. doi: 10.7554/eLife.10013.

22) Wang W, Wu J, Bernard K, Li G, Wang G, Bevensee MO, Kirk KL. ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.Proc Natl Acad Sci USA. 2010 Feb 23;107(8):3888-93. doi: 10.1073/pnas.0913001107.

23) Wu J, McNicholas CM, Bevensee MO. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes.Proc Natl Acad Sci USA. 2009 Aug 18;106(33):14150-5. doi: 10.1073/pnas.0906303106.

24) Wu J, Hablitz JJ. Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons.J Neurosci. 2005 Jul 6;25(27):6322-8. doi: 10.1523/JNEUROSCI.1405-05.2005.

25) Wu J, Piao H, Rojas A, Wang R, Wang Y, Cui N, Shi Y, Chen F, Jiang C. Critical protein domains and amino acid residues for gating the KIR6.2 channel by intracellular ATP.J Cell Physiol. 2004 Jan;198(1):73-81. doi: 10.1002/jcp.10388.

26) Wang X, Wu J, Li L, Chen F, Wang R, Jiang C. Hypercapnic acidosis activates KATP channels in vascular smooth muscles.Circ Res. 2003 Jun 13;92(11):1225-32. doi: 10.1161/01.RES.0000075601.95738.6D.

27) Wu J, Cui N, Piao H, Wang Y, Xu H, Mao J, Jiang C. Allosteric modulation of the mouse Kir6.2 channel by intracellular H⁺and ATP.J Physiol. 2002 Sep 1;543(Pt 2):495-504. doi: 10.1113/jphysiol.2002.025247.